A New Era of Loss on Drying Testing:
How Labthink C870 Series Delivers Automation, Accuracy, and Compliance
Understanding the Importance of Loss on Drying Testing
Loss on Drying (LOD) is one of the most widely used analytical methods for determining the loss of volatile substances in pharmaceutical, food, and chemical products.
By measuring the difference in sample weight before and after controlled drying, LOD testing provides valuable information about product characteristics, quality consistency, and compliance with industry requirements.
In pharmaceutical manufacturing, Loss on Drying is an important quality control parameter for raw materials, intermediates, and finished products. The content of moisture and other volatile components may directly influence product stability, processing performance, and storage conditions.
For decades, laboratories have relied on traditional manual LOD procedures. However, conventional workflows often involve multiple steps, including sample preparation, initial weighing, drying, cooling, repeated weighing, and manual calculation.
These operations require significant operator involvement and may introduce variations caused by environmental conditions, temperature changes, or human handling.
With increasing demands for laboratory automation, data integrity, and testing efficiency, automated Loss-on-Drying systems have become an important solution for modern quality control laboratories.
The Principle Behind Loss on Drying Testing
The principle of Loss on Drying testing is based on accurate gravimetric measurement.
Before testing, the empty test cup is dried, cooled, and weighed to obtain a stable reference weight. The prepared sample is then added into the cup and accurately weighed.
During the drying process, volatile substances are removed under controlled temperature conditions. After drying and cooling, the sample is weighed again.
The difference between the initial sample weight and the final dry weight represents the loss during drying, which is calculated as the Loss on Drying value.
Although the principle is simple, achieving reliable results requires precise control of drying and cooling conditions, accurate weighing technology, and effective elimination of environmental influences.
The Labthink C870 series follows this established testing principle while transforming traditional manual procedures into an automated workflow.
In our next article, we will explore...
How Labthink C870 Series Transforms Manual LOD Testing into an Automated Workflow